A Corkscrew Model for Dynamin Constriction
نویسندگان
چکیده
منابع مشابه
Dynamic remodeling of the dynamin helix during membrane constriction.
Dynamin is a dimeric GTPase that assembles into a helix around the neck of endocytic buds. Upon GTP hydrolysis, dynamin breaks these necks, a reaction called membrane fission. Fission requires dynamin to first constrict the membrane. It is unclear, however, how dynamin helix constriction works. Here we undertake a direct high-speed atomic force microscopy imaging analysis to visualize the const...
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The pleckstrin-homology domain of dynamin is dispensable for membrane constriction and fission
Classical dynamins bind the plasma membrane-localized phosphatidylinositol-4,5-bisphosphate using the pleckstrin-homology domain (PHD) and engage in rapid membrane fission during synaptic vesicle recycling. This domain is conspicuously absent among extant bacterial and mitochondrial dynamins, however, where loop regions manage membrane recruitment. Inspired by the core design of bacterial and m...
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k thermal conductivity, W/mK An analytical model is developed for predicting constriction and spreading resistances associated with heat transfer from various electronic components under different modes of cooling. The model assumes a heat source in contact with a larger cold plate which is in turn cooled with a convective heat transfer coefficient specified over the sink surface. Unlike existi...
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The mammalian dynamin-like protein DLP1 belongs to the dynamin family of large GTPases, which have been implicated in tubulation and fission events of cellular membranes. We have previously shown that the expression of a dominant-negative DLP1 mutant deficient in GTP hydrolysis (K38A) inhibited peroxisomal division in mammalian cells. In this study, we conducted RNA interference experiments to ...
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ژورنال
عنوان ژورنال: Structure
سال: 2007
ISSN: 0969-2126
DOI: 10.1016/j.str.2007.08.012